Isotretinoin is a retinoid form of chemotherapy that places an extreme level of stress on the human body. Depending on the dosage and length of treatment, the body may enter into a state of hypervitaminosis A, caused by ingesting 10 times the recommended daily allowance of vitamin A over a sustained period of time.
[Hypervitaminosis A] may be acute or chronic. Acute toxicity occurs after consuming large amounts of vitamin A over a short period of time, typically within a few hours or days. Chronic toxicity occurs when large amounts of vitamin A build up in your body over a long period of time. 
Isotretinoin (Accutane) is a Vitamin A derivative.
One of 20,000 genes in the body, the MTHFR gene is the blueprint for the MTHFR enzyme which plays a crucial role in the “Methylation Cycle.” The Methylation Cycle is a critical process occurring in every cell of the body, approximately once every second.
Some common mutations in the MTHFR gene result in an impairment of the Methylation Cycle. As a result, the body’s detoxification pathways can be reduced by as much as 90%. Neurotransmitter production can be impacted, affecting mental and emotional well being. DNA synthesis is affected. Over 200 processes in the body rely on the Methylation Cycle.
Because MTHFR gene mutations are common and impact the body’s detoxification pathways, being tested for these mutations is a foundational approach for looking at potential, underlying contributing factors to long term side effects from Accutane.
Importantly, the negative effects of MTHFR mutations can be mitigated, to varying degrees, through vitamin supplementation and lifestyle changes. In other words, if the MTHFR gene mutation is discovered, there are actionable steps to reducing the problems associated with it. These actionable steps can improve detoxification, neurotransmitter production, and improve support for the more than 200 processes in the body that rely on the Methylation Cycle.
While more protocols may be needed for healing from Accutane side effects (i.e., neurotransmitter rebalancing, restoring gut microbiome, addressing Vitamin D insufficiency, addressing fat digestion, addressing pharmaceutical overlays such as in the case of SSRI usage, etc…), knowing one’s MTHFR status illuminates potentially critical issues happening at the molecular level which, in essence, may be “jamming up” the body.
Additionally, MTHFR mutations have been implicated in over 600 different medical conditions. So the benefits of knowing one’s MTHFR status are wide ranging, even beyond recovering from Accutane side effects.