As previously stated, Isotretinoin is a vitamin A derivative (13-cis-retinoic acid). Generally, signs of vitamin A toxicity are associated with long-term consumption of vitamin A in excess of 10 times the RDA (8,000-10,000 μg RAE/day or 25,000-33,000 IU/day). 
10 times the maximum RDA is 250,000 to 330,000 IUs.
What is a Typical Dosage of Isotretinoin?
The dosage of isotretinoin for acne treatment can start as low as 0.5 mg per kg of body weight per day (0.5 mg/kg/day) and it can go up to a high dosage of 2 mg per kg of body weight per day. And intermediate dosage also exists for one mg per kg. 
Conversion from Lbs to Kg
Low Dose: 0.5mg/kg/day
175lb person = 79.37kg = 132,283 IUs
130lb person = 58.96kg = 98,266IUs
Intermediate Dose: 1mg/kg/day
175lb person = 79.37kg = 264,566 IUs
130lb person = 58.96kg = 196,533 IUs
High Dose: 2mg/kg/day
175lb person = 79.37kg = 529,132 IUs
130lb person = 58.96kg = 393,066 IUs
Again, 10 times the maximum RDA is 250,000 to 330,000 IUs.
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